WELCOME TO THE
COOMBES LAB
DEPARTMENT OF BIOCHEMISTRY & BIOMEDICAL SCIENCES
OUR LAB
Dr. Brian K. Coombes’ laboratory is in the Department of Biochemistry and Biomedical Sciences and the Michael G. DeGroote Institute for Infectious Disease Research at McMaster University. We are affiliated with the Michael G. DeGroote School of Medicine, a full-service research and teaching hospital located on the McMaster University campus. The McMaster campus is situated on 300 acres of property nestled in the Niagara escarpment. Hamilton is 45 minutes from Toronto.
The Center for Microbial Chemical Biology is a full-service high-throughput screening facility.
Dr. Brian K. Coombes’ laboratory is in the Department of Biochemistry and Biomedical Sciences and the Michael G. DeGroote Institute for Infectious Disease Research at McMaster University. We are affiliated with the Michael G. DeGroote School of Medicine, a full-service research and teaching hospital located on the McMaster University campus. The McMaster campus is situated on 300 acres of property nestled in the Niagara escarpment. Hamilton is 45 minutes from Toronto.
OUR RESEARCH IS GENEROUSLY SUPPORTED BY:
SELECTED RECENT PUBLICATIONS
2023
Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii
Nature Chemical Biology
G. Liu, D.B. Catacutan, K. Rathod, K. Swanson, W. Jin, J.C. Mohammed, A. Chiappino-Pepe, S.A. Syed, M. Fragis, K. Rachwalski, J. Magolan, M. G. Surette, B.K. Coombes, T. Jaakola, R. Barzilay, J.J. Collins, J.M. Stokes
2022
Genetic and chemical screening reveals targets and compounds to potentiate Gram-Positive antibiotics against Gram-Negative bacteria
ACS Infectious Diseases
K. Klobucar, E. Jardine, M. Farha, M. MacKinnon, M. Fragis, B. Nkonge, T. Bhando, L. Borrillo, C. Tsai, W. Johnson, B. Coombes, J. Magolan, E. Brown